منابع مشابه
Dermatoglyphic Assessment in Down and Klinefelter Syndromes
Background: Dermatoglyphics are the dermal ridge configurations on the digits, palms and soles. Dermatoglyphic polymorphism results from the co-operation of genetic and environmental factors. The Dermatoglyphic analysis is a valuable completion of initial diagnosis of some syndromes genetically determined. Our objective was to assess dermatoglyphics study results against standard chromosomal an...
متن کاملSuperficial multiple fibromatosis( combined 3 syndromes)
A 50 years old male patient to referred to our clinic for multiple hard diffused lesions on palms, plantars and penis. The Genesis of the problem goes back to 10 years earlier. The lesions appeared first on the soles and gradually new lesions appeared on the palms and eventually on the penis, so that stretching and contraction of the fingers and toes has become painful. During the last 6 years,...
متن کاملLifespan and Glucose Metabolism in Insulin Receptor Mutant Mice
Insulin/insulin-like growth factor type 1 signaling regulates lifespan and resistance to oxidative stress in worms, flies, and mammals. In a previous study, we revealed that insulin receptor (IR) mutant mice, which carry a homologous mutation found in the long-lived daf-2 mutant of Caenorhabditis elegans, showed enhanced resistance to oxidative stress cooperatively modulated by sex hormones and...
متن کاملSignal transduction pathways from insulin receptors to Ras. Analysis by mutant insulin receptors.
We have examined the involvement of insulin receptor (IR) substrate-1 (IRS-1) and/or Shc in the upstream of Ras activation in insulin signaling using Chinese hamster ovary (CHO) cell lines overexpressing wild-type (CHO-IR) cells) or mutant insulin receptors. In CHO-IR cells, insulin rapidly phosphorylated IRS-1 and Shc at tyrosine residues and stimulated the formation of the active GTP-bound Ra...
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ژورنال
عنوان ژورنال: Hormone and Metabolic Research
سال: 1988
ISSN: 0018-5043,1439-4286
DOI: 10.1055/s-2007-1010792